Systemic Gene Therapy for Cardiovascular Disease
نویسندگان
چکیده
منابع مشابه
Systemic gene therapy for cardiovascular disease.
Systemic gene therapy involves the transfer into the body of a gene whose protein product reaches the blood and has a beneficial effect on a patient. Both retroviral and adenovirus-associated viral vectors have resulted in stable but only moderate systemic levels of blood proteins. Adenoviral vectors have resulted in very high levels of expression that diminishes over days or weeks. Hepatic gen...
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Gene transfer within the cardiovascular system was first demonstrated in 1989 yet, despite extensive basic-science and clinical research, unequivocal benefit in the clinical setting remains to be demonstrated. Potential reasons for this include the fact that recombinant viral vectors, used in the majority of clinical studies, have inherent problems with immunogenicity that are difficult to circ...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 1999
ISSN: 1050-1738
DOI: 10.1016/s1050-1738(99)00023-7